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| 1755 |
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| Smallpox epidemic at the Cape. | 1 |
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| 1775–82 |
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| Series of succession disputes following the death of Xhosa ruler Phalo and his sons. | 2 |
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| c. 1776 |
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| First direct contacts between Dutch and Xhosa on the Zeekse River. | 3 |
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| 1779–81 |
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| First frontier war of a hundred-year series of wars between colonists of Cape and Xhosa on eastern frontier at Fish River. | 4 |
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| 1789 |
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| Xhosa crossed the Fish River. | 5 |
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| 1795 |
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| Whites rebelled against company rule on eastern frontier of South Africa. British captured Cape Town and put down rebellion. | 6 |
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| 1799 |
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| Khoi revolt on eastern frontier, supported by Khoi soldiers in British service. At this time there were 14,000 Khoi in the colony, cast in the role of intermediary between the settlement and Bantu farmers, but the rebellion ended this role in the east. | 7 |
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| 1800 |
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| Emergence in southeast coast among northern Nguni–speakers of larger chiefdoms that would become the Zulu state early in the next century, perhaps sparked by conflict over the ivory trade at Delagoa Bay or conflict over drought-stricken grazing land. (See Southern Africa) | 8 |
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